Spine
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Randomized Controlled Trial Comparative Study
Surgical versus nonoperative treatment for lumbar disc herniation: eight-year results for the spine patient outcomes research trial.
Concurrent prospective randomized and observational cohort studies. ⋯ 2.
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Randomized Controlled Trial Multicenter Study
Clinical outcomes with selectively constrained SECURE-C cervical disc arthroplasty: two-year results from a prospective, randomized, controlled, multicenter investigational device exemption study.
Prospective, multicenter, randomized, and controlled Investigational Device Exemption clinical trial. ⋯ 1.
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Randomized Controlled Trial Multicenter Study
rhBMP-2 for posterolateral instrumented lumbar fusion: a multicenter prospective randomized controlled trial.
Multicenter randomized controlled trial. ⋯ The use of rhBMP-2 for instrumented posterolateral lumbar surgery significantly improves the chances of radiographical fusion compared with the use of autograft. However, there is no associated improvement in clinical outcome within a 4-year follow-up period. These results suggest that use of rhBMP-2 should be considered in cases where lumbar arthrodesis is of primary concern.
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Randomized Controlled Trial
Effects of using intravenous antibiotic only versus local intrawound vancomycin antibiotic powder application in addition to intravenous antibiotics on postoperative infection in spine surgery in 907 patients.
A prospective randomized controlled trial. ⋯ The local application of vancomycin powder in surgical wounds did not significantly reduce the incidence of infection in patients with surgically treated spinal pathologies. The use of vancomycin powder may not be effective when incidence of infection is low.
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Randomized Controlled Trial
Natural history and risk factors for adjacent vertebral fractures in the fracture intervention trial.
Retrospective analysis of prospectively collected follow-up data for 2.9 years. ⋯ New vertebral fractures adjacent to prevalent fractures occurred relatively infrequently in this treatment trial of alendronate in females with osteoporosis, and were more common with older age at randomization, lower bone mineral density and placebo treatment.