Spine
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Comparative Study
Comparison of Bone Mineral Density in Children and Adolescents on CT Versus DEXA Scan.
Retrospective cross-sectional. ⋯ HU on lumbar CT in children and adolescents with DEXA Z -scores <-2.0, were lower when compared with healthy matched controls. This study suggests that HU on opportunistic CT scans of the spine may be used as a reasonable proxy for BMD in the pediatric population.
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Comparative Study Observational Study
Comparison of Patients Operated for Lumbar Spinal Stenosis with and without Spondylolisthesis - A Secondary Analysis of the NORDSTEN Trials.
Observational cohort study (secondary analysis of two randomized trials). ⋯ II.
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Retrospective cohort study. ⋯ L1PA may be a helpful radiographic consideration that translates to clinically relevant outcomes in spinal deformity. However, it does not appear as predictive of patient outcomes after single-level fusion for patients with L4-L5 degenerative spondylolisthesis. Further studies are warranted to investigate the role of L1PA in degenerative spine patients.
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Retrospective analysis of prospectively collected data. ⋯ Level II.
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This study was aimed to investigate the potential roles of circTMTC1 in the underlying pathophysiological mechanisms of ossification of the ligamentum flavum (OLF). ⋯ Our findings suggested the circTMTC1-DDX3X-NLRP3 inflammasome signaling plays a pivotal role in osteogenic differentiation of human ligamentum flavum cells, which may provide novel diagnostic and therapeutic strategies for OLF.