Intensive care medicine
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Intensive care medicine · Aug 2002
Randomized Controlled Trial Comparative Study Clinical TrialInfluence of respiratory rate on gas trapping during low volume ventilation of patients with acute lung injury.
Reduction in tidal volume (Vt) associated with increase in respiratory rate to limit hypercapnia is now proposed in patients with acute lung injury (ALI). The aim of this study was to test whether a high respiratory rate induces significant intrinsic positive end-expiratory pressure (PEEPi) in these patients. ⋯ An increase in respiratory rate used to avoid Vt reduction-induced hypercapnia may induce substantial gas trapping and PEEPi in patients with ALI.
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Intensive care medicine · Aug 2002
Oxygenation index, an indicator of optimal distending pressure during high-frequency oscillatory ventilation?
To test the hypothesis that, during high-frequency oscillatory ventilation (HFOV) of pigs with acute lung injury, the oxygenation index (OI = Paw*FIO(2)*100/PaO(2)) is minimal at the lowest continuous distending pressure (Paw), where the physiological shunt fraction is below 0.1 (Paw(optimal)). ⋯ The minimal OI is indicative for the Paw where oxygenation is optimal during HFOV in surfactant-depleted pigs.
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Intensive care medicine · Aug 2002
Comparative StudyChanges in intensive care from 1987 to 1997 - has outcome improved? A single centre study.
To study changes in a single intensive care unit (ICU) over a 10 year period and to investigate possible concomitant changes in outcome. ⋯ This study indicates that the increased intensive care activity over the 10 year period was associated with a prolonged severity-adjusted survival. QOL was still reduced 3 and 13 years after ICU, compared to population scores.