Intensive care medicine
-
Intensive care medicine · Nov 2003
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialEarly antibiotic treatment (prophylaxis) of septic complications in severe acute necrotizing pancreatitis: a prospective, randomized, multicenter study comparing two regimens with imipenem-cilastatin.
We compared two imipenem regimens for prevention of septic complications in patients with severe acute necrotizing pancreatitis (ANP). ⋯ Compared to a 14-day imipenem prophylaxis, a longer antibiotic administration in patients with ANP is not associated with a reduction in the incidence of septic complications of the disease. However, prolonged imipenem administration in patients with persisting systemic complications tends to reduce mortality in ANP compared to a 14-days regimen.