Intensive care medicine
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Intensive care medicine · May 2003
Randomized Controlled Trial Multicenter Study Clinical TrialEarly enteral immunonutrition in patients with severe sepsis: results of an interim analysis of a randomized multicentre clinical trial.
To compare the mortality of critically ill patients given either enteral feeding with an immune-enhancing formula or parenteral nutrition (PN). We report the results of a planned interim analysis on patients with severe sepsis which was undertaken earlier than planned once a meta-analysis suggested excess mortality in patients with severe sepsis given enteral immunonutrition. ⋯ Our results show that enteral immunonutrition, compared to PN, may be associated with excess mortality in patients with severe sepsis.