Intensive care medicine
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Intensive care medicine · Mar 2007
Multicenter StudyIncidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study.
To determine the incidence and outcome of severe sepsis in the adult Finnish population and to evaluate how treatment guidelines in severe sepsis are applied in clinical practice. ⋯ This prospective study found the incidence of ICU-treated severe sepsis in Finland to be 0.38 per 1,000 of the population. The ICU and hospital mortalities were also lower than earlier reported in United States or Australia. Evidence-based sepsis therapies were not used as often as recommended.
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Intensive care medicine · Mar 2007
Multicenter StudyEvaluating the use of Drotrecogin alfa (activated) in adult severe sepsis: a Canadian multicenter observational study.
The purpose of this study was to characterize the usage patterns and clinical outcomes of DAA in Ontario and Quebec over a 1-year period. ⋯ Mortality and bleeding complications associated with the use of DAA were higher than that reported in randomized trials but similar to other usage database. This may be due to the higher severity of illness seen in this cohort of patients. Modifiable risks associated with mortality and bleeding, such as time to treatment, and knowledge of relative contraindications should be targets of further research and future educational efforts in order to optimize the risk-to-benefit ratio of DAA.