Intensive care medicine
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Intensive care medicine · Dec 2015
Circulating phthalates during critical illness in children are associated with long-term attention deficit: a study of a development and a validation cohort.
Environmental phthalate exposure has been associated with attention deficit disorders in children. We hypothesized that in children treated in the pediatric intensive care unit (PICU), circulating phthalates leaching from indwelling medical devices contribute to their long-term attention deficit. ⋯ Iatrogenic exposure to DEHP metabolites during intensive care was independently and robustly associated with the important attention deficit observed in children 4 years after critical illness. Clinicaltrials.gov identifier: NCT00214916.