Intensive care medicine
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Intensive care medicine · Feb 2015
Evaluation of endothelial damage in sepsis-related ARDS using circulating endothelial cells.
Endothelial cell activation and dysfunction are involved in the pathophysiology of ARDS. Circulating endothelial cells (CECs) may be a useful marker of endothelial dysfunction and damage but have been poorly studied in ARDS. We hypothesized that the CEC count may be elevated in patients with sepsis-related ARDS compared to those with sepsis without ARDS. ⋯ The day-1 CEC count was significantly higher in ARDS patients than in other critically ill patients, and in moderate or severe ARDS patients compared to those with milder disease, making it a potentially useful marker of ARDS severity.
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Intensive care medicine · Feb 2015
Editorial CommentPredicting the determinants of volume responsiveness.