Intensive care medicine
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Intensive care medicine · Feb 2015
Multicenter StudyDamage control resuscitation using blood component therapy in standard doses has a limited effect on coagulopathy during trauma hemorrhage.
To determine the effectiveness of blood component therapy in the correction of trauma-induced coagulopathy during hemorrhage. ⋯ Damage control resuscitation with standard doses of blood components did not consistently correct trauma-induced coagulopathy during hemorrhage. There is an important opportunity to improve TIC management during damage control resuscitation.
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Dysglycemia is a characteristic feature of critical illness associated with adverse outcome. Whether dysglycemia contributes to brain dysfunction during critical illness and long-term neurological complications is unclear. We give an overview of glucose metabolism in the brain and review the literature on critical illness-induced dysglycemia and the brain. ⋯ Preventing hyperglycemia during critical illness holds promise as a neuroprotective strategy to preserve brain cell viability and prevent acute brain dysfunction and long-term cognitive impairment in survivors.
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Intensive care medicine · Feb 2015
Multicenter Study Observational StudyVolume expansion in the first 4 days of shock: a prospective multicentre study in 19 French intensive care units.
To describe the current practices of volume expansion in French intensive care units (ICU). ⋯ High between-centre variability characterised all the aspects of FB prescription and monitoring, but overall haemodynamic exploration to help guide and monitor FB was infrequent.
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Intensive care medicine · Feb 2015
Multicenter StudyPrognosis of neutropenic patients admitted to the intensive care unit.
The prognosis of critically ill cancer patients has improved recently. Controversies remain as regard to the specific prognosis impact of neutropenia in critically ill cancer patients. The primary objective of this study was to assess hospital outcome of critically ill neutropenic cancer patients admitted into the ICU. The secondary objective was to assess risk factors for unfavorable outcome in this population of patients and specific impact of neutropenia. ⋯ Hospital survival was closely associated with younger age and neutropenic enterocolitis. Conversely, need for conventional MV, for renal replacement therapy, and allogeneic hematopoietic stem cell transplantation (HSCT) were associated with poor outcome.