Intensive care medicine
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Intensive care medicine · Apr 2016
Randomized Controlled Trial Multicenter Study Comparative StudyHigher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial.
In shock, hypotension may contribute to inadequate oxygen delivery, organ failure and death. We conducted the Optimal Vasopressor Titration (OVATION) pilot trial to inform the design of a larger trial examining the effect of lower versus higher mean arterial pressure (MAP) targets for vasopressor therapy in shock. ⋯ This pilot study supports the feasibility of a large trial comparing lower versus higher MAP targets for shock. Further research may help delineate the reasons for vasopressor dosing in excess of prescribed targets and how individual patient characteristics modify the response to vasopressor therapy.