Intensive care medicine
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Intensive care medicine · Feb 2017
Randomized Controlled Trial Multicenter StudyHigh flow nasal cannula (HFNC) versus nasal continuous positive airway pressure (nCPAP) for the initial respiratory management of acute viral bronchiolitis in young infants: a multicenter randomized controlled trial (TRAMONTANE study).
Nasal continuous positive airway pressure (nCPAP) is currently the gold standard for respiratory support for moderate to severe acute viral bronchiolitis (AVB). Although oxygen delivery via high flow nasal cannula (HFNC) is increasingly used, evidence of its efficacy and safety is lacking in infants. ⋯ In young infants with moderate to severe AVB, initial management with HFNC did not have a failure rate similar to that of nCPAP. This clinical trial was recorded in the National Library of Medicine registry (NCT 02457013).
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Intensive care medicine · Feb 2017
Multicenter StudySevere hypercapnia and outcome of mechanically ventilated patients with moderate or severe acute respiratory distress syndrome.
To analyze the relationship between hypercapnia developing within the first 48 h after the start of mechanical ventilation and outcome in patients with acute respiratory distress syndrome (ARDS). ⋯ Severe hypercapnia appears to be independently associated with higher ICU mortality in patients with ARDS.