Intensive care medicine
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Intensive care medicine · Jul 2018
Review Meta AnalysisOut-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis.
Discharge from an intensive care unit (ICU) out of hours is common. We undertook a systematic review and meta-analysis to explore the association between time of discharge and mortality/ICU readmission. ⋯ Out-of-hours discharge from an ICU is strongly associated with both in-hospital death and ICU readmission. These effects persisted across all definitions of "out of hours" and across healthcare systems in different geographical locations. Whether these increases in mortality and readmission result from patient differences, differences in care, or a combination remains unclear.
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Intensive care medicine · Jul 2018
Review Meta Analysis Comparative StudyLow-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis.
To assess the effect of low dose corticosteroids on outcomes in adults with septic shock. ⋯ In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced. PROSPERO registration no. CRD42017084037.