Intensive care medicine
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Intensive care medicine · Feb 2019
Case ReportsThe accidental discovery of a tracheal diverticulum.
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Intensive care medicine · Feb 2019
EditorialOxygen and carbon dioxide targets during and after resuscitation of cardiac arrest patients.
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Intensive care medicine · Feb 2019
EditorialPhysiological interventions in cardiac arrest: passing the pilot phase.
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Intensive care medicine · Feb 2019
Review Meta AnalysisStress ulcer prophylaxis with proton pump inhibitors or histamin-2 receptor antagonists in adult intensive care patients: a systematic review with meta-analysis and trial sequential analysis.
Most intensive care unit (ICU) patients receive stress ulcer prophylaxis. We present updated evidence on the effects of prophylactic proton pump inhibitors (PPIs) or histamine 2 receptor antagonists (H2RAs) versus placebo/no prophylaxis on patient-important outcomes in adult ICU patients. ⋯ In this updated systematic review, we were able to refute a relative change of 20% of mortality. The occurrence of GI bleeding was reduced, but we lack firm evidence for a reduction in clinically important GI bleeding. The effects on SAEs, HRQoL, pneumonia, myocardial ischemia and Cl. difficile enteritis remain inconclusive.
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Intensive care medicine · Feb 2019
Randomized Controlled Trial Multicenter StudyInfluence of the initial level of consciousness on early, goal-directed mobilization: a post hoc analysis.
Early mobilization within 72 h of intensive care unit (ICU) admission improves functional status at hospital discharge. We aimed to assess the effectiveness of early, goal-directed mobilization in critically ill patients across a broad spectrum of initial consciousness levels. ⋯ This post hoc analysis of a randomized controlled trial suggests that early, goal-directed mobilization in patients with an impaired initial conscious state (GCS ≤ 8) is not harmful but effective.