Intensive care medicine
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Intensive care medicine · Feb 2019
Future of the ICU: finding treatable needles in the data haystack.
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Intensive care medicine · Feb 2019
EditorialPhysiological interventions in cardiac arrest: passing the pilot phase.
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Intensive care medicine · Feb 2019
Comment LetterAssessment of respiratory mechanics during pressure support ventilation? Caution required.
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Intensive care medicine · Feb 2019
EditorialTreatment with a polymyxin B filter to capture endotoxin in sepsis patients: is there a signal for therapeutic efficacy?
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Intensive care medicine · Feb 2019
Review Meta AnalysisStress ulcer prophylaxis with proton pump inhibitors or histamin-2 receptor antagonists in adult intensive care patients: a systematic review with meta-analysis and trial sequential analysis.
Most intensive care unit (ICU) patients receive stress ulcer prophylaxis. We present updated evidence on the effects of prophylactic proton pump inhibitors (PPIs) or histamine 2 receptor antagonists (H2RAs) versus placebo/no prophylaxis on patient-important outcomes in adult ICU patients. ⋯ In this updated systematic review, we were able to refute a relative change of 20% of mortality. The occurrence of GI bleeding was reduced, but we lack firm evidence for a reduction in clinically important GI bleeding. The effects on SAEs, HRQoL, pneumonia, myocardial ischemia and Cl. difficile enteritis remain inconclusive.