Intensive care medicine
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Intensive care medicine · May 2019
Whole genome sequencing reveals that genetic conditions are frequent in intensively ill children.
With growing evidence that rare single gene disorders present in the neonatal period, there is a need for rapid, systematic, and comprehensive genomic diagnoses in ICUs to assist acute and long-term clinical decisions. This study aimed to identify genetic conditions in neonatal (NICU) and paediatric (PICU) intensive care populations. ⋯ The use of WGS in intensively ill children is acceptable and trio analysis facilitates diagnoses. A gene agnostic approach was effective in identifying an underlying genetic condition, with phenotypes and symptomatology being primarily used for data interpretation rather than gene selection. WGS analysis has the potential to be a first-line diagnostic tool for a subset of intensively ill children.
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Intensive care medicine · May 2019
Modifiable elements of ICU supportive care and communication are associated with surrogates' PTSD symptoms.
To identify specific components of ICU clinician supportive care and communication that are associated with increased post-traumatic stress disorder (PTSD) symptoms for surrogate decision makers of patients with chronic critical illness (CCI). ⋯ Modifiable deficits in ICU clinician support and communication were associated with increased PTSD symptoms among CCI surrogates.