Intensive care medicine
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Intensive care medicine · May 2019
Randomized Controlled Trial Multicenter StudyA multicenter, randomized, double-blind study of ulimorelin and metoclopramide in the treatment of critically ill patients with enteral feeding intolerance: PROMOTE trial.
Enteral feeding intolerance (EFI) is a frequent problem in the intensive care unit (ICU), but current prokinetic agents have uncertain efficacy and safety profiles. The current study compared the efficacy and safety of ulimorelin, a ghrelin agonist, with metoclopramide in the treatment of EFI. ⋯ Both prokinetic agents achieved similar rates of feeding success, and no safety differences between the two treatment groups were observed.