Intensive care medicine
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Intensive care medicine · May 2021
Multicenter StudyEvolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months.
Clinical characteristics and management of COVID-19 patients have evolved during the pandemic, potentially changing their outcomes. We analyzed the associations of changes in mortality rates with clinical profiles and respiratory support strategies in COVID-19 critically ill patients. ⋯ Age and mortality rates have declined over the first 8 months of the pandemic. The use of NIRS as the first respiratory support measure was associated with survival, but causal inference is limited by the observational nature of our data.
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Intensive care medicine · May 2021
Randomized Controlled TrialRandomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia.
The life-saving role of oxygen therapy in African children with severe pneumonia is not yet established. ⋯ Respiratory support with HFNT showing potential benefit should prompt further trials.