Intensive care medicine
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Intensive care medicine · Mar 2024
Randomized Controlled Trial Multicenter StudyRenal replacement therapy initiation strategies in comatose patients with severe acute kidney injury: a secondary analysis of a multicenter randomized controlled trial.
The effect of renal replacement therapy (RRT) in comatose patients with acute kidney injury (AKI) remains unclear. We compared two RRT initiation strategies on the probability of awakening in comatose patients with severe AKI. ⋯ In comatose patients with severe AKI, a more-delayed RRT initiation strategy resulted in a lower chance of transitioning from coma to awakening.
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Intensive care medicine · Mar 2024
Multicenter Study Observational StudyReactivation of Epstein-Barr virus among intensive care patients: a prospective observational study.
Herpesvirus reactivation has been documented among patients in the intensive care unit (ICU) and is associated with increased morbidity and mortality, particularly for cytomegalovirus (CMV). Epstein-Barr virus (EBV) has been poorly studied despite >95% of the population being seropositive. Our preliminary study suggested an association between EBV reactivation and increased morbidity and mortality. This study aimed to investigate this association among patients admitted to the ICU. ⋯ While EBV reactivation was not associated with increased 90-day mortality, it was associated with significantly increased morbidity.