Clinical therapeutics
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Clinical therapeutics · Apr 2008
Randomized Controlled Trial Multicenter Study Comparative StudyEffects of carvedilol on left ventricular function and oxidative stress in infants and children with idiopathic dilated cardiomyopathy: a 12-month, two-center, open-label study.
This study was conducted to determine the effects of carvedilol adjunct to standard treatment on left ventricular function (LVF), estimated as ejection fraction (EF) and fractional shortening (FS) on echocardiography, in children with idiopathic dilated cardiomyopathy (DCM). A secondary end point was to characterize the antioxidant potential of carvedilol. ⋯ These pediatric patients with DCM treated for 12 months with carvedilol (up to 0.8 mg/kg/d in children
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Clinical therapeutics · Apr 2008
Randomized Controlled Trial Multicenter Study Comparative StudyHospital resource utilization with doripenem versus imipenem in the treatment of ventilator-associated pneumonia.
Ventilator-associated pneumonia (VAP) is a common nosocomial infection that is associated with prolonged length of stay (LOS) and significant mortality. ⋯ Of the 3 primary end points in this analysis, hospital LOS and time on mechanical ventilation were significantly shorter with doripenem compared with imipenem; no statistical significance was observed in ICU LOS. These findings suggest that doripenem use may be associated with an economic and clinical benefit to patients and hospitals.