Clinical therapeutics
-
Clinical therapeutics · Oct 2013
Review Meta AnalysisProphylactic midazolam and clonidine for emergence from agitation in children after emergence from sevoflurane anesthesia: a meta-analysis.
Emergence agitation (EA) after emergence from sevoflurane anesthesia is a common phenomenon in children. The efficacy of prophylactic midazolam or clonidine in preventing EA is controversial. ⋯ This meta-analysis suggests that prophylactic administration of midazolam or clonidine could significantly decrease the incidence of sevoflurane-induced EA in pediatric patients.
-
Clinical therapeutics · Oct 2013
Meta Analysis Comparative StudyEvaluation of antiplatelet agents for secondary prevention of stroke using mixed treatment comparison meta-analysis.
The current guidelines recommend various antiplatelet agents used alone or in combination for secondary prevention of noncardioembolic stroke. ⋯ We found that ASA plus DP was more protective than ASA alone for preventing recurrent stroke; however, no difference was found between most direct and indirect comparisons of antiplatelet agents and combinations. More overall hemorrhagic events seemed to occur with the combination of ASA and clopidogrel than with other treatments. Selection of antiplatelet therapy for the secondary prevention of stroke must be individualized according to patient comorbidities, including risk of stroke recurrence and bleeding.