Clinical therapeutics
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Clinical therapeutics · Feb 2013
Randomized Controlled Trial Comparative StudyPharmacokinetic comparison of acetaminophen elixir versus suppositories in vaccinated infants (aged 3 to 36 months): a single-dose, open-label, randomized, parallel-group design.
Because of practical problems and ethical concerns, few studies of the pharmacokinetics (PK) of acetaminophen (ACET) in infants have been published. ⋯ No statistically significant differences were found between the rates or extent of absorption of the suppository and elixir preparations in this small, infant population. Both preparations were well tolerated. Vaccinated infants were a useful population in which to conduct a PK study of this antipyretic, analgesic product. Delays in publishing pediatric trials can occur as a result of a number of issues even when results are positive.
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Clinical therapeutics · Feb 2013
Randomized Controlled Trial Multicenter StudyNebivolol monotherapy for patients with systolic stage II hypertension: results of a randomized, placebo-controlled trial.
Elevated systolic blood pressure (SBP) is an independent risk factor for cardiovascular events and mortality. ⋯ NEB monotherapy was an efficacious and well-tolerated treatment option for these study individuals with systolic stage II hypertension, but most of them would need combination therapy to achieve BP control.