Clinical therapeutics
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Clinical therapeutics · Apr 2013
ReviewEffect of azithromycin on anticoagulation-related outcomes in geriatric patients receiving warfarin.
Warfarin is known to have multiple pharmacokinetic and pharmacodynamic interactions. Of the macrolide family, erythromycin and clarithromycin have been shown to interact with warfarin, leading to an elevated international normalized ratio (INR). The incidence of overanticoagulation in patients prescribed azithromycin stabilized on a warfarin regimen is controversial. ⋯ The addition of azithromycin to a stable warfarin regimen resulted in a significant change in the INR and warfarin dosage alteration without an increase in bleeding.