Clinical therapeutics
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The industry has adopted Clinical Data Interchange Standards Consortium standards for clinical trial data and the Food and Drug Administration electronic common technical document standard for documents for many years but still faces many challenges. The solutions based on these standards enable integration among solo systems, but the integration needs to be based on business requirements and provides the end-to-end intelligence for the business. ⋯ Automation that uses artificial intelligence and machine learning will be the next game changer in the industry to provide data with higher quality and more efficiency. This article discusses the challenges in managing standards adoption, potential approaches for automation through using robotic processes, artificial intelligence, and the maturity model for metadata-driven automation in clinical research.
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Clinical therapeutics · Nov 2019
Randomized Controlled Trial Comparative StudyComparison of the Level of Free Hexafluoro-isopropanol in Adults' Blood and the Incidence of Emergence Agitation After Anesthesia With Different Concentrations of Sevoflurane in Laparoscopic Gastrointestinal Surgery: A Randomized Controlled Clinical Trial.
The aim of the study is to compare the free hexafluoro-isopropanol (HFIP) concentration in adults' blood and the incidence of emergence agitation (EA) after inhaled different concentrations of sevoflurane. ⋯ The generation of HFIP would be inhibited when the inhaled sevoflurane concentration increased to 1.5 MAC. However, the incidence of EA during recovery had nothing to do with the inhaled different sevoflurane concentrations (within 1.5 MAC) in adults. ChicCTR.org identifier: ChiCTR-IPD-17011558.