Revista de neurologia
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Revista de neurologia · Oct 2007
Review[A proposed new target for deep brain stimulation in obsessive-compulsive disorder].
The obsessive-compulsive disorder (OCD) has an incidence in general population of 1.5-3%. If we consider as a positive respond a diminution of the 25-35% in the symptoms of OCD according to the Y-BOCS, and we add the cognitive-behavioral therapy to the pharmacological treatment, only a 40-60% of treated patients would have significant improvement and a 10% of patients with OCD, would be refractory to all type of medical treatment. ⋯ This article has as target the demonstration that bilateral DBS of the limbic part of the subthalamic nucleus is an alternative for the treatment of refractory OCD.
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Revista de neurologia · Jul 2007
Review[An update on neurochemistry and pharmacological therapy of the cerebellar ataxias].
To review the available neurochemical data on the different cerebellar ataxias, and the therapeutic trials undertaken in the last twenty-five years. ⋯ A systematic search for treatable ataxias is emphasized, as a response to the severity of the degenerative conditions. The use of GABAergic drugs is proposed in ataxias associated with a deficiency of GABA in the brain, and that of glutamatergic agents, for ataxias associated with glutamate deficiency. The use of serotoninergic and cholinergic drugs is ruled out due to insufficient neurochemical evidence. It is proposed that research on remedies for the cerebellar ataxias should be based on either molecular data, or on neurochemical data, in its defect. To this end, the study of animal or experimental models of ataxia, the use of objective methods for the measurement of ataxia, and the recruitment of homogenous study populations, are all recommended.
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Revista de neurologia · May 2007
Review Historical Article[Telemedicine and dementia: a need for the 21st century].
The ongoing process of information and communication technologies in health services implies a change in the conception, organization and management of these services. Telemedicine is a working method that allows health professionals to explore and/or treat a patient from an off-site location. In this review we provide a historical background on telemedicine, the evolution of its bibliometric impact, and its application for people with dementia. ⋯ Dementia could be an appropriate field in order to implement some telemedicine programs that may improve patient medical care, and reduce medical and management expenses for social and healthcare services.
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Revista de neurologia · Jan 2007
Review[Biomedical publications in Spain on debate (II): the on-going 'revolutions' and their application to neurological journals].
To debate about the application of on-going 'revolutions' in medical knowledge to Spanish neurological journals in the 21st century. This article reviews the current status of five revolutions in the field of health sciences, in general, and in neurological sciences, in particular: 1) the knowledge revolution: to translate the scientific investigation to the patient, with knowledge needs-driven research agenda with founder commissioning research to answer questions posed by clinicians, managers and patients, and systematic and critical appraisal reviews as the creator of quality improved knowledge; 2) the evidence based medicine revolution: the pyramid information of '4S', with systems (guidelines and computerized decision support systems), synopses (secondary journals), syntheses (systematic reviews and meta-analysis) and studies (original studies published in journals); 3) the web revolution: the possibility of dissemination of biomedical documentation by means of the Internet network are producing changes in the traditional way of conceiving scientific publication; the Internet represents a great advantage for investigation and also for clinical practice, since it permits free, universal access to databases and the interchange of texts, images and videos; 4) the open access revolution: to take full control over all operations related to the process of publish (to create, publish, communicate, distribute, reproduce and transform) with no need of any intermediaries, and to transform fundamental aspects concerning the circulation of knowledge, its use and availability; and 5) the librarian revolution: the project of a Virtual Health Library in Spain as a tool to access and disseminate scientific and technical knowledge on health through the Internet.
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Revista de neurologia · Jan 2007
Review[Biomedical publications in Spain on debate (I): state of neurological journals].
Bibliometric studies belong to the so-called 'social studies of science', and science policy constitutes one of its main applied fields, providing objective and useful tools for evaluating the results of scientific activity. Neurological sciences are very important in the bibliometric map of Spain about biomedicine and health sciences, from a quantitative (second thematic area in productivity, only after biology-biochemical) and a qualitative (high health costs and morbimortality) point of view. ⋯ The Acuerdo de Buenos Aires is an initiative to promote scientific neurological papers of high quality in Spanish. The current status of neurological journals in the bibliometric context of our country is good and open to the advantages of electronic and free access.