Annals of neurology
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Annals of neurology · Sep 2008
Randomized Controlled TrialBotulinum toxin type A induces direct analgesic effects in chronic neuropathic pain.
Botulinum toxin type A (BTX-A) has been reported to have analgesic effects independent of its action on muscle tone, possibly by acting on neurogenic inflammation. Such a mechanism may be involved in peripheral neuropathic pain. ⋯ These results indicate for the first time that BTX-A may induce direct analgesic effects in patients with chronic neuropathic pain independent of its effects on muscle tone and suggest novel indications for BTX-A in analgesia.