Annals of neurology
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Annals of neurology · Dec 2015
Randomized Controlled TrialSimvastatin and vitamin D for migraine prevention: A randomized, controlled trial.
The aim of this work was to assess efficacy and tolerability of simvastatin plus vitamin D for migraine prevention in adults with episodic migraine. ⋯ The results demonstrate that simvastatin plus vitamin D is effective for prevention of headache in adults with episodic migraine. Given statins' ability to repair endothelial dysfunction, this economical approach may also reduce the increased risk for vascular diseases among migraineurs.