Annals of neurology
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Annals of neurology · Dec 2020
Randomized Controlled TrialHypersensitivity to Calcitonin Gene-Related Peptide in Post-Traumatic Headache.
To demonstrate that calcitonin gene-related peptide (CGRP) induces headache exacerbation with migraine-like features in patients with persistent post-traumatic headache (PTH) attributed to mild traumatic brain injury (TBI). ⋯ Patients with persistent PTH are hypersensitive to CGRP, which underscores its pathophysiological importance. Furthermore, CGRP-targeted therapies might provide a novel mechanism-based treatment option for patients with persistent PTH. ANN NEUROL 2020;88:1220-1228.