Annals of neurology
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Annals of neurology · May 2014
Randomized Controlled Trial Multicenter StudyPhysical activity and amyotrophic lateral sclerosis: a European population-based case-control study.
To assess whether physical activity is a risk factor for amyotrophic lateral sclerosis (ALS). ⋯ Physical activity is not a risk factor for ALS and may eventually be protective against the disease.
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Annals of neurology · Feb 2014
Randomized Controlled TrialHyperbaric oxygen for blast-related postconcussion syndrome: three-month outcomes.
Mild traumatic brain injury (mTBI) and postconcussion syndrome (PCS) are common among military combatants. Hyperbaric oxygen (HBO2 ) is a proposed treatment for these conditions, but it has not been rigorously studied. The objective of this study was to determine the effects of HBO2 by 3 months post compression at 2 commonly employed dosing levels to treat PCS; whether specific subgroups may have benefited; and if no overall effect was found, whether benefit is masked by other conditions. ⋯ Using a randomized control trial design and analysis including a sham, results showed no evidence of efficacy by 3 months post-compression to treat the symptomatic, cognitive, or behavioral sequelae of PCS after combat-related mTBI.
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Annals of neurology · Nov 2013
Randomized Controlled TrialEteplirsen for the treatment of Duchenne muscular dystrophy.
In prior open-label studies, eteplirsen, a phosphorodiamidate morpholino oligomer, enabled dystrophin production in Duchenne muscular dystrophy (DMD) with genetic mutations amenable to skipping exon 51. The present study used a double-blind placebo-controlled protocol to test eteplirsen's ability to induce dystrophin production and improve distance walked on the 6-minute walk test (6MWT). ⋯ Eteplirsen restored dystrophin in the 30 and 50 mg/kg/wk cohorts, and in subsequently treated, placebo-controlled subjects. Duration, more than dose, accounted for dystrophin production, also resulting in ambulation stability. No severe adverse events were encountered.
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Annals of neurology · Apr 2013
Randomized Controlled TrialElevated temperature and 6- to 7-year outcome of neonatal encephalopathy.
A study was undertaken to determine whether higher temperature after hypoxia-ischemia is associated with death or intelligence quotient (IQ)<70 at 6 to 7 years among infants treated with intensive care without hypothermia. ⋯ Among noncooled infants of a randomized trial, elevated temperatures during the first postnatal days are associated with increased odds of a worse outcome at 6 to 7 years.
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Annals of neurology · Jan 2013
Randomized Controlled Trial Multicenter StudyPredictors of long-term outcome in multiple sclerosis patients treated with interferon β.
To identify early predictors of long-term outcomes in patients with relapsing-remitting multiple sclerosis (RRMS) treated with intramuscular (IM) interferon beta-1a (IFNβ-1a). ⋯ Disease activity despite treatment with IFNβ is associated with unfavorable long-term outcomes. Particular attention should be paid to gadolinium-enhancing lesions on IFNβ therapy, as their presence strongly correlates with severe disability 15 years later. The results provide rationale for monitoring IFNβ-treated patients with MRI, and for changing therapy in patients with active disease.