The Journal of physiology
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The Journal of physiology · Aug 1980
Cerebral blood flow and oxidative metabolism during hypoxia and asphyxia in the new-born calf and lamb.
1. The effects of hypoxia and asphyxia on cerebral blood flow and oxidative metabolism have been investigated in the calf and lamb under sodium pentobarbitone anaesthesia. 2. Cerebral blood flow was determined using a hydrogen clearance technique, and cerebral metabolism quantified by the simultaneous measurement of arteriocerebral venous concentration differences for oxygen, glucose and lactate. ⋯ Cerebral glucose uptake did not change, but cerebral oxygen consumption was markedly depressed, and the glucose-oxygen index increased. 6. In the lamb during normoxia, there was a linear correlation between cerebral blood flow and arterial PCO2 in the range 10-95 mmHg (r = 0.92; P < 0.001), with a slope of 1.74 ml. 100g-1 min-1 . mmHg Pa,CO2-1. Hypoxia did not significantly increase the fall in cerebral vascular resistance associated with a rise in Pa,CO2 from 34 to 56 mmHg.