MMWR. Morbidity and mortality weekly report
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MMWR Morb. Mortal. Wkly. Rep. · Jan 2000
Case ReportsAccutane-exposed pregnancies--California, 1999.
Accutane (Roche Laboratories, Nutley, New Jersey), known by the generic name "isotretinoin," is a prescription oral medication approved by the Food and Drug Administration (FDA) to treat severe, recalcitrant nodular acne. It is also a known human teratogen that can cause multiple major malformations. Embryopathy associated with the mother's exposure to isotretinoin during the first trimester of pregnancy includes craniofacial, cardiac, thymic, and central nervous system malformations. ⋯ Although isotretinoin is contraindicated in pregnancy and has a package label warning users to avoid pregnancy while taking it, exposed pregnancies occur. Approximately 900 pregnancies occurred among BUAS enrollees during 1989-1998 (BUAS, unpublished data, 1999). Roche Laboratories began direct-to-consumer print advertisements in 1996, added television and radio advertisements to selected cities in 1997, and expanded the campaign to the entire United States in 1998.
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MMWR Morb. Mortal. Wkly. Rep. · Jan 2000
Case ReportsHypothermia-related deaths--Alaska, October 1998-April 1999, and trends in the United States, 1979-1996.
Hypothermia is defined as an unintentional lowering of the core body temperature to < or = 95 F (< or = 35 C) (1). It is a medical emergency with a high fatality rate (2). ⋯ From October 1998 through April 1999, 16 deaths attributed to hypothermia (International Classification of Diseases, Ninth Revision [ICD-9], codes E901.0, E901.8, and E901.9; excludes man-made cold [E901.1]) were reported to the Alaska State Medical Examiner. This report describes selected cases of hypothermia-related deaths in Alaska during October 1998-April 1999; compares age-, sex-, and race-specific rates in Alaska and the rest of the United States during 1979-1996; and summarizes trends for hypothermia-related deaths in the United States during 1979-1996.