Ophthalmology
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Randomized Controlled Trial Multicenter Study
Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE.
To evaluate the efficacy and safety of intravitreal ranibizumab in diabetic macular edema (DME) patients. ⋯ Ranibizumab rapidly and sustainably improved vision, reduced the risk of further vision loss, and improved macular edema in patients with DME, with low rates of ocular and nonocular harm.
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Meta Analysis Comparative Study
Topical anesthesia versus regional anesthesia for cataract surgery: a meta-analysis of randomized controlled trials.
To examine possible differences in the clinical outcomes of topical anesthesia (TA) and regional anesthesia including retrobulbar anesthesia (RBA) and peribulbar anesthesia (PBA) in phacoemulsification. ⋯ Compared with RBA/PBA, TA does not provide the same excellent pain relief in cataract surgery; however, it achieves similar surgical outcomes. Topical anesthesia reduces injection-related complications and alleviates patients' fear of injection. The choice of TA is not suitable for patients with a higher initial blood pressure or greater pain perception.