The American journal of medicine
-
Randomized Controlled Trial Multicenter Study Clinical Trial
A randomized trial of hydroxychloroquine in early rheumatoid arthritis: the HERA Study.
Studies of the efficacy of hydroxychloroquine in rheumatoid arthritis have had methodological flaws and have failed to produce definitive results. The benefits and toxicity of hydroxychloroquine sulfate in 120 patients with rheumatoid arthritis of less than 2 years duration are assessed. ⋯ Over 36 weeks, hydroxychloroquine had a significant benefit on synovitis, pain, and physical disability of recent-onset rheumatoid arthritis, but did not benefit psychological function.