The American journal of medicine
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Randomized Controlled Trial Multicenter Study Clinical Trial
Efficacy of metformin in type II diabetes: results of a double-blind, placebo-controlled, dose-response trial.
To study the efficacy and safety of various dosages of metformin as compared with placebo in patients with type II diabetes mellitus. ⋯ Metformin lowered fasting plasma glucose and HbA1c generally in a dose-related manner. Benefits were observed with as little as 500 mg of metformin; maximal benefits were observed at the upper limits of the recommended daily dosage. All dosages were well tolerated. Metformin appears to be a useful therapeutic option for physicians who wish to titrate drug therapy to achieve target glucose concentrations.