The American journal of medicine
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Randomized Controlled Trial Clinical Trial
Long-term maintenance of weight loss after a very-low-calorie diet: a randomized blinded trial of the efficacy and tolerability of sibutramine.
Very-low-calorie diets are a well established method to achieve substantial short-term weight loss in obese patients, but long-term maintenance of the weight loss is very disappointing. A combined very-low-calorie diet and pharmacologic approach could be an effective means of prolonging its benefits. ⋯ Following a very-low-calorie diet, sibutramine is effective in maintaining and improving weight loss for up to 1 year.