The American journal of medicine
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Randomized Controlled Trial Clinical Trial
Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults.
In our initial study of the potential effects of cholesterol-lowering interventions on cognitive functioning, treatment with lovastatin as compared with placebo caused performance decrements on several neuropsychological tests, whereas scores on other tests were unaffected. The current study was designed to confirm and extend those findings. ⋯ This study provides partial support for minor decrements in cognitive functioning with statins. Whether such effects have any long-term sequelae or occur with other cholesterol-lowering interventions is not known.