The American journal of medicine
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Randomized Controlled Trial Multicenter Study Comparative Study
Comparing COPD treatment: nebulizer, metered dose inhaler, and concomitant therapy.
Patients using albuterol and ipratropium for treating chronic obstructive pulmonary disease (COPD) can use either nebulizers or metered dose inhalers. This study compared the 2 methods of delivering medication and the concomitant use of both nebulizer and inhaler, with respect to health-related quality of life, patient symptoms, and efficacy. ⋯ Patients using combined nebulizer therapy morning and night with mid-day inhaler use had the most statistically significant improvements in quality of life indices. This concomitant regimen provides the additional symptom relief offered by a nebulizer with the convenience of an inhaler when patients are away from home.
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Randomized Controlled Trial
A randomized, controlled, trial of controlled release paroxetine in fibromyalgia.
We investigated the efficacy and tolerability of paroxetine controlled release, a selective serotonin reuptake inhibitor in fibromyalgia. ⋯ Paroxetine controlled release appears to be well-tolerated and improve the overall symptomatology in patients with fibromyalgia without current mood or anxiety disorders. However, its effect on pain measures seems to be less robust.
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Randomized Controlled Trial Multicenter Study
Bupropion for smokers hospitalized with acute cardiovascular disease.
Smoking cessation after myocardial infarction reduces cardiovascular mortality, but many smokers cannot quit despite state-of-the-art counseling intervention. Bupropion is effective for smoking cessation, but its safety and efficacy in hospitalized smokers with acute cardiovascular disease is unknown. ⋯ Bupropion improved short-term but not long-term smoking cessation rates over intensive counseling and appeared to be safe in hospitalized smokers with acute cardiovascular disease.
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Randomized Controlled Trial
A randomized, double-blind, placebo-controlled trial of nutritional supplementation during acute illness.
The study tested whether nutritional support of older patients during acute illness leads to a clinical benefit. ⋯ Oral nutritional supplementation of acutely ill patients improved nutritional status and led to a statistically significant reduction in the number of non-elective readmissions.
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Randomized Controlled Trial Multicenter Study
Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study.
To evaluate the efficacy and upper gastrointestinal (UGI) safety of celecoxib, compared with nonspecific nonsteroidal anti-inflammatory drugs (NSAIDs), among patients with osteoarthritis. ⋯ In the treatment of osteoarthritis, celecoxib is as effective as the nonspecific NSAIDs naproxen and diclofenac, but has significantly fewer serious upper gastrointestinal events.