The American journal of medicine
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This paper reviews the current literature pertaining to calcium channel blockers, including their classification, properties, and therapeutic indications, in light of several recent trials that have addressed their safety. Calcium channel blockers are a structurally and functionally heterogeneous group of medications that are used widely to control blood pressure and manage symptoms of angina. They are classified as dihydropyridines or nondihydropyridines. ⋯ Even so, the use of these agents has been linked with an increased risk of heart failure. Thus, long-acting calcium channel blockers may be safely used in the management of hypertension and angina. However, as a class, they are not as protective as other antihypertensive agents against heart failure.
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Multicenter Study
Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome.
Severe obesity is associated with hypoventilation, a disorder that may adversely affect morbidity and mortality. We sought to determine the prevalence and effects of obesity-associated hypoventilation in hospitalized patients. ⋯ Hypoventilation frequently complicates severe obesity among hospitalized adults and is associated with excess morbidity and mortality.
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To determine the incidence of perioperative events in patients with aortic stenosis undergoing noncardiac surgery. ⋯ Aortic stenosis is a risk factor for perioperative mortality and nonfatal myocardial infarction, and the severity of aortic stenosis is highly predictive of these complications.