Neurosurgery
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Case Reports Randomized Controlled Trial Clinical Trial
Intrathecal octreotide for relief of intractable nonmalignant pain: 5-year experience with two cases.
Somatostatin is distributed in the substantia gelatinosa in the dorsal horn of the spinal cord, and its application has been found to produce an inhibitory effect on nociceptive neurons. Although intraspinal administration of somatostatin-14 produces pain relief in patients with cancer and in postoperative patients, its short half-life limits its clinical usefulness. ⋯ This article describes the 5-year clinical course of two patients receiving intrathecal octreotide for severe, intractable nonmalignant pain. Included in this description are the results of blinded, randomized "N of 1" trials conducted in each of these patients.
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Ischemia is one of the major factors causing secondary brain damage after severe head injury. We have investigated the value of continuous partial pressure of brain tissue oxygen (PbrO2) monitoring as a parameter for cerebral oxygenation in 22 patients with severe head injury (Glasgow Coma Scale score, < or = 8). Jugular bulb oxygenation, intracranial pressure, and cerebral perfusion pressure were simultaneously recorded. ⋯ The early occurrence of ischemia after head injury can be monitored on a continuous basis. Deficiency of oxygen autoregulatory mechanisms can be demonstrated, and their occurrence is inversely related to outcome. For practical clinical use, the method seemed to be superior to jugular oximetry.
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We described a new ventricular catheter that is the combination of a "classic" ventricular catheter with a piezo-resistive transducer at its tip. The device allows parallel recordings of intraventricular fluid pressure via a chip and a fluid-filled external transducer, drainage of cerebrospinal fluid from the ventricle or injection of fluid into the ventricle with simultaneous monitoring of intracranial pressure, and recording of brain tissue pressure in cases of misplacement or dislocation of the ventricular catheter or in cases of progressively narrowing ventricles caused by brain edema. Clinical tests in various situations at different pressure ranges (total recording time, 1356 h in 13 patients) gave excellent correlations of both pressures. Application of the device is especially indicated in clinical situations in which pressure-controlled drainage is desirable, occlusion of ventricular bolts is likely, or pressure-volume tests are needed.
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Hyponatremia is frequently seen in neurosurgical patients and is often attributed to inappropriate secretion of antidiuretic hormone. A number of studies in recent years have shown that hyponatremia in many patients with intracranial disease may actually be caused by cerebral salt wasting, in which a renal loss of sodium leads to hyponatremia and a decrease in extracellular fluid volume. The appropriate treatment of cerebral salt wasting fluid and salt replacement, is opposite from the usual treatment of hyponatremia caused by inappropriate secretion of antidiuretic hormone. This review summarizes the evidence in favor of cerebral salt wasting in patients with intracranial disease, examines the possible mechanisms responsible for this phenomenon, and discusses methods for diagnosis and treatment.
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Comparative Study
Laboratory testing of three intracranial pressure microtransducers: technical report.
Three comparatively priced intracranial pressure (ICP) microtransducers are now available, each characterized by the manufacturer as having very low zero drift over long periods, an excellent frequency response, and a low measurement error. The three microtransducers, coded Transducer A (Camino OLM ICP monitor; Camino Laboratories, San Diego, CA), Transducer B (Codman Microsensor ICP Transducer; Codman & Shurtlef Inc., Randolph, MA), and Transducer C (ICP Monitoring Catheter Kit OPX-SD [4F]; InnerSpace Medical, Irvine, CA), were examined in a pressure-flow test rig designed for assessment of hydrocephalus shunts. All three microtransducers compiled with the manufacturers' specifications and gave high-quality readings under test conditions. ⋯ Transducer A had a static error < 0.3 mm Hg, Transducer B < 2 mm Hg, and Transducer C < 8 mm Hg. Frequency detection in Transducers A and B were very good (bandwidth, > 30 Hz), whereas Transducer C had a limited bandwidth of 20 Hz. Transducer B scored the best overall, but all three scored satisfactorily during bench testing.