Neurosurgery
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Randomized Controlled Trial Multicenter Study
Epidural cortical stimulation of the left dorsolateral prefrontal cortex for refractory major depressive disorder.
A significant number of patients with major depressive disorder are unresponsive to conventional therapies. For these patients, neuromodulation approaches are being investigated. ⋯ Epidural cortical stimulation of the left dorsolateral prefrontal cortex appears to be a safe and potentially efficacious neuromodulation approach for treatment-refractory major depressive disorder.