Neurosurgery
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Comparative Study
Persistent outpatient hyperglycemia is independently associated with decreased survival after primary resection of malignant brain astrocytomas.
Patients with malignant brain astrocytomas are at high risk for developing hyperglycemia secondary to frequent corticosteroid administration. Several clinical studies have shown that hyperglycemia is associated with poor outcome in multiple disease states. Furthermore, hyperglycemia augments in vitro astrocytoma growth, whereas hypoglycemia attenuates in vitro astrocytoma cell growth. We hypothesized that persistent hyperglycemic states in the outpatient setting may serve as a prognostic marker of decreased survival in patients with malignant brain astrocytomas. ⋯ In our experience, persistent outpatient hyperglycemia was associated with decreased survival in patients undergoing surgical resection for malignant astro- cytomas and was independent of the degree of disability, tumor grade, diabetes, prolonged dexamethasone use, or subsequent treatment modalities. Increased glucose control is warranted in this patient population and may contribute to improved outcomes in the treatment of malignant brain astrocytomas.
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The issue of whether sports-related head trauma at the youth level can result in long-term sequelae that may negatively impact the participant has been widely debated. ⋯ We demonstrate that there are few head impacts over the course of an entire season at the middle school level. Guardian Caps, safe tackling techniques, and the age of participants may have contributed to the very low number of impacts recorded and the complete lack of injuries. This study only provides data demonstrating that youth football, when Guardian Caps and safe tackling techniques are enforced, does not appear to result in significant head impacts causing immediate head injuries. This study cannot comment on the safety of playing football at the collegiate or professional level.