Pacing and clinical electrophysiology : PACE
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Pacing Clin Electrophysiol · Aug 2012
Review Case ReportsIsolated tramadol overdose associated with Brugada ECG pattern.
Tramadol is a commonly prescribed synthetic opioid analgesic. In humans, electrocardiogram (ECG) changes consistent with sodium-channel blockade have not been described in overdoses with tramadol. ⋯ However, in vitro blockade of sodium-channels has been demonstrated with high concentrations of tramadol. Tramadol overdose should be recognized as a cause for the manifestation of a Brugada ECG pattern in the setting of suicidal intoxication.