Pacing and clinical electrophysiology : PACE
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Pacing Clin Electrophysiol · Aug 2013
Meta AnalysisTiming and route of amiodarone for prevention of postoperative atrial fibrillation after cardiac surgery: a network regression meta-analysis.
We attempted to evaluate if an oral-only regimen was as effective in preventing postoperative atrial fibrillation (POAF) after cardiac surgery, in comparison to a regimen that included intravenous (IV) administration using a network meta-analysis of available data, and also attempted to assess if preoperative administration at least 1 day before surgery was superior to postoperative prophylaxis (at least 1 day after surgery). ⋯ This systematic review suggests a regimen of both oral-only and one including IV administration, as well pre- and postoperative administration of amiodarone is effective in prevention of POAF after cardiac surgery.