Pathology, research and practice
-
Pathol. Res. Pract. · Jan 2020
Review Meta AnalysisThe different role of PD-L1 in head and neck squamous cell carcinomas: A meta-analysis.
Programmed cell death-ligands 1 (PD-L1) is a promising immune target for tumor immunotherapy. We conducted this meta-analysis to investigate association between PD-L1 expression and clinicopathological characteristics of head and neck squamous cell carcinomas (HNSCC). Electronic databases were searched for eligible studies. ⋯ However, the higher PD-L1 expression in tumor cells indicated a better DFS of OPSCC (HR = 0.34, 95 %CI: 0.18-0.67). This meta-analysis demonstrated that PD-L1 overexpression in HNSCC associated with female patients. However, no significant difference was observed in OS or DFS, except the DFS in OPSCC.
-
Pathol. Res. Pract. · Sep 2019
Meta AnalysisAssociation of CAV1 polymorphisms with the risks of breast cancer: A systematic review and meta-analysis.
Caveolin-1 (CAV1) polymorphisms have been shown to correlated with breast cancer risk in previous studies. However, the role of CAV1 polymorphisms still remained indecisive, and dual functions of CAV1 was demonstrated in breast cancer development. Consequently, a meta-analysis to evaluate and summarize the association of the CAV1 polymorphisms with breast cancer susceptibility. ⋯ CAV1 rs3807987 and rs7804372 polymorphisms are associated with the change of breast cancer risk. More well-designed and large studies in various populations are needed to further elaborate these associations.
-
Pathol. Res. Pract. · Jan 2019
Meta AnalysisCAV1 polymorphisms rs1049334, rs1049337, rs7804372 might be the potential risk in tumorigenicity of urinary cancer: A systematic review and meta-analysis.
Background As an integral membrane, Caveolin-1 (CAV1), is a pivotal component to make up the caveolae protein. It has been demonstrated to influence tumorigenicity, including bladder, colon, liver, stomach, breast and lung cancer. Several publications had illustrated the relationship of between CAV1 polymorphism and urinary cancer, but the results were not consistent. ⋯ The GTEx in-silico analysis index that the polymorphism of CAV1 influence its mRNA expression by a dose-dependent effective of its mutant allele. Conclusion rs1049334 polymorphismof CAV1 upgrade the risk of urinary cancer, while rs1049337 and rs7804372 polymorphisms may act as a protector of urinary cancer. Further large and well-designed studies in various populations are needed to confirm the results.
-
Pathol. Res. Pract. · Dec 2010
Meta AnalysisPathological research output in China and other top-ranking countries: 10-year survey of the literature.
The present study was designed to study the research output in pathology journals from the United States (USA), Japan, Germany, the United Kingdom (UK), France, and China between 2000 and 2009. Articles published in 67 pathology-related journals were retrieved from the PubMed database. ⋯ Our analysis investigated the research output of these six countries and revealed a positive trend in China for the period 2000-2009. Also, in contrast to other top-ranking countries, our results imply that China's research in the field of pathology falls behind that of the developed countries, and appropriate steps should be taken to improve the role of pathologists in clinical activity and to gear up for high-quality pathological studies.