Irish journal of medical science
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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for coronavirus disease 19 (COVID-19), has rapidly spread since December 2019 to become the focus of healthcare systems worldwide. Its highly contagious nature and significant mortality has led to its prioritization as a public health issue. ⋯ Currently, there is no robust clinical evidence for the use of these drugs in the treatment of COVID-19, with most, if not all of these medications associated with the potential for QT interval prolongation, torsades de pointes, and resultant drug-induced sudden cardiac death. The aim of this document is to help healthcare providers mitigate the potential deleterious effects of drug-induced QTc prolongation.
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Celiac disease (CD) is a chronic intestinal immune-mediated disease occurring in genetically susceptible individuals who are exposed to gluten. Although it primarily affects the small intestine, CD has been associated with a wide spectrum of extraintestinal manifestations, including thromboembolism and cardiovascular events. ⋯ The pathogenetic mechanism of increasing hypercoagulability in CD is multifactorial and involves hyperhomocysteinemia due to malabsorption of vitamins B12, B6, and folic acid; endothelial dysfunction; acceleration of atherosclerosis; chronic inflammation; thrombocytosis; and thrombophilia. Therefore, in cases of thromboembolic complications and cardiovascular disease of obscure etiology, clinicians' awareness of possible celiac disease is warranted.
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Review Meta Analysis
The prevalence of premenstrual dysphoric disorder among adolescents in Ethiopia: a systematic review and meta-analysis.
The rates of prevalence of premenstrual dysphoric disorder (PMDD) in Ethiopia were high and inconsistent across studies. However, there was no previous systematic reviews and meta-analysis conducted on this topic. Therefore, this review aimed to systematically review previous studies on the topic and summarize the prevalence of PMDD among students in Ethiopia and formulate recommendations for future clinical services. ⋯ Further, the pooled estimated prevalence of premenstrual dysphoric disorder was ranging from 51.2 to 57.2% in leave-one-out sensitivity analysis, suggesting that the removal of one study did not affect the overall prevalence estimate. The pooled estimated prevalence of premenstrual dysphoric disorder among female students in Ethiopia was high. Early screening and appropriate interventions at primary healthcare settings are warranted.
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Randomized Controlled Trial
Role of nebulized epinephrine in moderate bronchiolitis: a quasi-randomized trial.
Bronchiolitis is the most common lower respiratory illness that characteristically affects the children below 2 years of age accounting about 2-3% of patients admitted to hospital each year [1-4]. We compared the effect of racemic epinephrine (RE) and 3% hypertonic saline (HS) nebulization on the length of stay (LOS) in the hospital. ⋯ Racemic epinephrine nebulization as first-line medication may significantly reduce the length of hospital stay in infants with moderate bronchiolitis in comparison with nebulized HS.