Irish journal of medical science
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We summarized through systematic review and meta-analysis of observational studies the risk of mortality as well as severe illness of COVID-19 caused by omicron variant relative to delta variant of SARS-CoV-2. A total of twelve studies were included. Our results showed significantly reduced odds of mortality (pooled OR = 0.33; 95% CI: 0.16-0.67) and significantly reduced odds of severe illness (pooled OR = 0.24; 95% CI: 0.21-0.28) in patients infected with the omicron variant of SARS-CoV-2 relative to their counterparts infected with the delta variant. Findings of lower disease severity following infection with the omicron variant of SARS-CoV-2 than the delta variant are encouraging during the ongoing transition from the pandemic phase into the endemic phase of COVID-19.
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To assess clinical efficacy and safety of liraglutide combined with metformin (LMT) in obese patients with type 2 diabetes (ODP) by conducting a meta-analysis of randomized controlled trials (RCTs). ⋯ This review will offer insights for future research and provide reference for LMT treatment for ODP.
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The COVID-19 pandemic saw the migration of many physiotherapy-led group exercise programmes towards online platforms. This online survey aimed to ascertain the patients' views of online group exercise programmes (OGEP), including their satisfaction with various aspects of these programmes, the advantages and disadvantages and usefulness beyond the pandemic. ⋯ Patients expressed high satisfaction rates overall with online classes, but would value more opportunities for social interaction. Although 50% of respondents would choose in-person classes in the future, offering both online and in-person classes beyond the pandemic may help to suit the needs of all patients and improve attendance and adherence.
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We present key information from international registries in relation to primary total hip arthroplasty. The specific questions of interest include which bearings are superior in total hip arthroplasty (THA), which fixation types are optimal, do any specific implants perform better than others, and what is the latest update in the hip fracture setting? This is a comprehensive review of the major English-speaking hip arthroplasty registries across the globe. Key trends and developments in implant performance are identified and presented in the current article. Key points from review of all registries confirm that ceramic-on-polyethylene and metal-on-polyethylene continue to be the commonest bearings. ⋯ Dual mobility (DM) bearings are increasing in use and show higher early revision rates than unipolar bearings-they tend to be used for more complex indications (fracture/tumor/revision) and show similar revision rates to unipolar bearings when used exclusively in primary elective THA for osteoarthritis. We present current trends in THA based on current registry data from across the globe. Clinical signals of concern are emerging for THA uncemented femoral stem fixation and DM bearings in specific clinical contexts. These signals should be monitored across the literature in order to reduce the overall revision burden.
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Review Case Reports
An unusual case of a giant fetal facial tumour and review of the literature.
We present the case of a pregnant 32-year-old woman who presented with a giant fetal facial tumour at 22 weeks. The mass, initially 4 × 3.5 × 3 cm in size, was largely cystic with a small solid component. It subsequently increased to 9 × 9 × 10 cm. ⋯ Postnatally, the baby had significant compression and displacement of the craniofacial skeleton from the mass effect. Postnatal histology revealed a diagnosis of a teratoma. This case highlights the complexities and challenges surrounding the diagnosis and management of a giant fetal facial tumour.