Journal of manipulative and physiological therapeutics
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J Manipulative Physiol Ther · Oct 1998
Randomized Controlled Trial Clinical TrialThe efficacy of spinal manipulation, amitriptyline and the combination of both therapies for the prophylaxis of migraine headache.
Migraine headache affects approximately 11 million adults in the United States. Spinal manipulation is a common alternative therapy for headaches, but its efficacy compared with standard medical therapies is unknown. ⋯ There was no advantage to combining amitriptyline and spinal manipulation for the treatment of migraine headache. Spinal manipulation seemed to be as effective as a well-established and efficacious treatment (amitriptyline), and on the basis of a benign side effects profile, it should be considered a treatment option for patients with frequent migraine headaches.