Sleep
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Randomized Controlled Trial Multicenter Study Clinical Trial
A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease.
To determine the safety and efficacy of 2 dose formulations of melatonin for the treatment of insomnia in patients with Alzheimer's disease. ⋯ Based on actigraphy as an objective measure of sleep time, melatonin is not an effective soporific agent in people with Alzheimer's disease.