Hearing research
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Comparative Study
Functional responses from guinea pigs with cochlear implants. I. Electrophysiological and psychophysical measures.
We examined electrophysiological and psychophysical measures of the electrically stimulated auditory system of guinea pigs implanted with chronic intracochlear electrodes. Guinea pigs were trained to detect low-level acoustic stimuli and then unilaterally deafened and implanted with one extracochlear and two intracochlear electrodes. Electrically evoked auditory brainstem responses (EABRs) and psychophysical detection thresholds were obtained from the same animals using pulsatile stimuli. ⋯ Differences between EABR and psychophysical strength-duration measures suggest the existence of central mechanisms of stimulus integration in addition to that occurring at the level of the auditory nerve. Differences observed with variation of stimulus parameters (e.g., monopolar vs. bipolar stimulation modes) suggest that the specific mode of intracochlear electrical stimulation can influence stimulus integration. Such observations may be useful in the design of prosthetic devices and furthering our understanding of electrical excitation of the auditory system.
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The purpose of the investigation was to correlate the functional properties of primary auditory fibres with the location of appertaining receptor cells in the avian basilar papilla. The functional properties of 425 single afferent fibres from the auditory nerve of adult pigeons were measured. The peripheral innervation site of 39 fibres was identified by intracellular labelling and correlated with the fibre's functional properties. ⋯ Their Q10 dB was less than average but their sensitivity and SR were comparable to the mean population values. It is concluded that functional properties change gradually not only along the length but also across the width of the pigeon basilar papilla. The results support the idea that sharp frequency tuning of avian primary auditory fibres involves tuning mechanisms supplementary to the tuning of the free part of the basilar membrane.
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Hair cell regeneration after acoustic trauma has been conclusively documented in birds. Previous studies of aminoglycoside ototoxicity have typically used 5-10 day courses of drug to damage the cochlea and trigger regeneration. This long-term lesion prevented analysis of the early events of regeneration. ⋯ Two-week survivors showed an elevation in hair cell number compared to controls in regions which had sustained damage and immediately adjacent regions. This elevation implies that an overproduction of hair cells might occur as part of the regeneration response. By 5 weeks after damage hair cell numbers approximated controls.
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Nerve-fiber regeneration in the chinchilla cochlea following a traumatic noise exposure was systematically described by Bohne and Harding (1992). However, their study did not determine the origin of the regenerated nerve fibers (RNFs). In the present study, 23 chinchillas were exposed for 12 h to a 0.5 kHz octave band of noise at 120 dB SPL. ⋯ In the AChE-stained cochleas, none of the RNFs were AChE-positive, but normal AChE-positive fibers were found in the undamaged apical turn. A variable number of surviving spiral ganglion cells was present in those regions of Rosenthal's canal that had originally innervated the missing hair cells in the OC wipeouts and remnants. It is concluded that RNFs are not part of the efferent cochlear system and therefore, most likely belong to the afferent system.
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The middle latency responses (MLR) to acoustical stimulation (A-MLR) as well as to electrical stimulation (E-MLR) of the inner ear were recorded in pentobarbital-anaesthetised cats. Monopolar and bipolar MLR recordings were performed with electrodes located at different places on the primary auditory cortex (AI). The cochlea was electrically stimulated (ES) through a single round-window electrode or through a multichannel intracochlear implant. ⋯ Parameters of E-MLRs evoked by high-frequency ( > 4 kHz) and low-intensity ES in hearing cats, which produced an electrophonic effect, were similar to parameters of acoustically evoked MLRs. In deafened cats, the properties of responses to extracochlear ES were different from those recorded to acoustical stimulation and they were almost uniform in all cortical places. Variations in thresholds, in latencies and in the slope of the amplitude-intensity functions of the E-MLRs recorded in individual tonotopical cortical places were observed when the auditory nerve was stimulated with different configurations of electrodes through a multichannel intracochlear implant.