Digestive diseases and sciences
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Randomized Controlled Trial Multicenter Study Comparative Study
Antidepressant therapy (imipramine and citalopram) for irritable bowel syndrome: a double-blind, randomized, placebo-controlled trial.
The efficacy of antidepressants in irritable bowel syndrome (IBS) is controversial. No trials have directly compared a tricyclic with a selective serotonin reuptake inhibitor. Our aim was to determine whether imipramine and citalopram are efficacious in IBS. ⋯ Neither imipramine nor citalopram significantly improved global IBS endpoints over placebo.
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Randomized Controlled Trial Comparative Study
Remifentanil compared with midazolam and pethidine sedation during colonoscopy: a prospective, randomized study.
The objective of our study was to compare the safety and efficacy of remifentanil during colonoscopy with those of the standard combination of midazolam and pethidine. ⋯ Remifentanil during colonoscopy provides sufficient pain relief with better hemodynamic stability, less respiratory depression, and significantly faster recovery and hospital discharge than moderate sedation with midazolam and pethidine.