Japanese journal of clinical oncology
-
Jpn. J. Clin. Oncol. · Dec 2015
Meta AnalysisGemcitabine plus S-1: a hopeful frontline treatment for Asian patients with unresectable advanced pancreatic cancer.
Gemcitabine-based chemotherapy is widely used for unresectable advanced pancreatic cancer which contains locally advanced and metastatic pancreatic cancer. We performed meta-analysis to examine whether gemcitabine plus S-1 could improve treatment efficacy as first-line chemotherapy for those patients when compared with gemcitabine alone. ⋯ This meta-analysis confirmed the survival benefits of gemcitabine plus S-1 as first-line treatment for unresectable advanced pancreatic cancer at least in Asia, while good Eastern Cooperative Oncology group performance status was warranted. Importantly, we highlighted the significant overall survival benefit of gemcitabine plus S-1 in locally advanced patients but not in metastatic patients.
-
Jpn. J. Clin. Oncol. · Nov 2015
Review Meta AnalysisSystematic review and network meta-analysis: neoadjuvant chemoradiotherapy for locoregional esophageal cancer.
Neoadjuvant chemoradiotherapy improves survival in patients with locoregional esophageal cancer. This study compares the efficacy of two common regimens, paclitaxel plus platinum and platinum plus 5-fluorouracil, based on overall survival. ⋯ Neoadjuvant chemoradiotherapy with paclitaxel plus platinum regimen seemed to be a better treatment than platinum plus 5-fluorouracil regimen for locoregional esophageal cancer, especially for squamous cell carcinoma.
-
Jpn. J. Clin. Oncol. · Sep 2014
Meta AnalysisBody mass index and risk of gastric cancer: a meta-analysis.
Overweight and obesity, indicated as increased body mass index, are associated with the risk of some cancers. We carried out a meta-analysis on published cohort and case-control studies to assess the strength of association between body mass index and gastric cancer. ⋯ The results indicated that obesity was associated with the risk of gastric cancer, especially for males and among non-Asians. Both overweight and obesity were associated with the risk of gastric cardia cancer.
-
Jpn. J. Clin. Oncol. · Sep 2013
Meta AnalysisSystematic evaluation of prophylactic neck dissection for the treatment of papillary thyroid carcinoma.
The objective of the study was to evaluate the efficacy of prophylactic neck dissection in the treatment of papillary thyroid cancer and to provide guidelines for clinical practice. ⋯ Combined thyroidectomy and prophylactic neck dissection may be effective in the treatment of patients with papillary thyroid cancer, without more complications compared with thyroidectomy alone.